convolvulus prostratus common name
convolvulus prostratus common name
Park C., Moon D. O., Rhu C. H., Choi B. T., Lee W. H., Kim G. Y., et al. Domnguez-Avila J., Gonzlez-Aguilar G., Alvarez-Parrilla E., de la Rosa L. (2016). Similar results have also been observed in case of the ethanolic extract of the CP flower petals at doses 200400 mg/Kg in mice (Kaushik, 2017). Sethiya N. K., Nahata A., Mishra S. H., Dixit V. K. (2009). Federal government websites often end in .gov or .mil. A few examples of such marketed herbal pharmaceutical formulations include Patanjali Divya Shankhpushpi Churna, Divya Pharmacy Shankhpushpi Sharbat, Baidyanath Shankhpushpi Sharbat, Dabur Shankhpushpi Syrup, Biotrex Shankhpushpi, Maxmind capsule, Herbal Hills Shankhpushpi Tablets and many more (Bhowmik etal., 2012). The chemotherapeutic moieties used currently for the treatment of neurological disorders face a daunting challenge of systemic delivery of the drugs to the central nervous system. In addition, CP is known to be a good source of vitamins and minerals, namely, calcium, copper, iron, magnesium, manganese, phosphorus, potassium, sulphur, zinc, vitamin C and E (Sethiya etal., 2010; Babu etal., 2015). The reactive oxygen species are known to deteriorate the cellular physiology of nerve cells and ultimate lead to neurodegenerative disorders. The aqueous extract of the roots of C. prostratus inhibited the activity of acetylcholinesterase (AChE) within the cortex and hippocampus of male Wistar rats, that have been intoxicated with scopolamine. More specifically, a compound, namely, 29-oxodotriacontanol, isolated from the CP herb has also been assessed to possess antimicrobial and anti-fungal activity (Amin etal., 2014). Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and Amyloid precursor protein (APP) expression in rat brain. There was increase in the time spent in open arms; and in the number of open arm entries upon the CP oral administration to mice at a dose of 200 mg/Kg (Bhalerao etal., 2014). (2018). Several drug delivery vehicles and nano-formulations have been devised so as to facilitate the targeted delivery of the drug to the site of action, i.e., the central nervous system, thereby bypassing the blood brain barrier (Saraiva etal., 2016; Tonda-Turo etal., 2018). Shankpushpi- which species? Secondly, the muscarinic receptors bind to the neurotransmitter acetylcholine, thereby facilitating the transmission of electrical signals within the central nervous system (Brown, 2018). Synthesis of convolinine and cytotoxic activity of alkaloids of the genus Convolvulus and their derivatives, Vinholes J., Silva B. M., Silva L. R. (2015). Furthermore, the presence of GABA-A-benzodiazepine agonists, such as convolamine, scopoletin, ceryl alcohol, kaempferol, phytosterol, and -sitosterol endow this herb with hypotensive and sedative activities (Malik etal., 2011; Siddiqui etal., 2014). Ravichandra V. D., Ramesh C., Sridhar K. A. Fungitoxic effect of scopolin and related coumarins on Sclerotinia sclerotiorum - A way to overcome sunflower head rot. Rathee P., Chaudhary H., Rathee S., Rathee D., Kumar V., Kohli K. (2009). The The most common disorders of the nervous system are schizophrenia (~ 40% prevalence in India) and epilepsy (~ 45% prevalence in India), which are clinically presented by dysfunction of the interneurons, misbalancing neuronal homeostasis, ultimately leading to neurophysiological disintegration (Gururaj etal., 2005). Among these phytoconstituents, certain compounds are known to be present at a higher concentration (almost 20% w/w) and are known as major phyto-constituents. Such sedative activity is directly linked to the presence of phytoconstituents like convolamine and scopoletin which act similarly to GABA-A agonists, thereby bringing about the effects of sedation ( My apologies, sir, I got this photo from somebody else. Learn more These phytoconstituents have well-described antioxidant and anti-inflammatory properties which aids in protecting the neuronal cells against oxidative stress. PT analyzed the information, generated the artwork, and co-wrote the manuscript. All authors agreed with the final version of this manuscript. Ekhlas M. M. Abdel Bary, The Flora of Qatar, Volume I: The Dicotyledons. Scopoletin is a phytoalexin against Alternaria alternata in wild tobacco dependent on jasmonate signalling. Similarly, a polyherbal formulation (Trans-01) containing C. prostratus (30%), Valeriana wallichii (45%), Plumbago zeylanica (7.5%), Boswellia serrata (15%) and Acorus calamus (3.5%) also exhibited similar anti-depressant properties as tested by employing the forced swim test (FST), tail suspension test (TST) and forced swimming stress (FSS)-induced alterations in serum corticosterone levels. All the above mentioned ethnomedicinal uses of C. prostratus have been tabulated in Sethiya N. K., Trivedi A., Patel M. B., Mishra S. H. (2010). Figure1A This Medicinal plants-related article is a stub. Ultimately, the bioavailability of these drugs becomes low and therefore, lead to below- optimal efficacies (Tonda-Turo etal., 2018). (2015). As per an ancient Indian medicinal scriptureCharaka Samhitathis plant is superior to other nootropic drugs (Medhya rasayana) of Ayurveda, however, a detailed ethnomedicinal update yet needs to be presented (Dev, 2006). The fundamental bioactive compounds responsible for the nootropic activities of this herb have been identified as 4'-methoxy kaempferol, 7-methoxy quercetin, convolamine, scopoletin, ceryl alcohol, -sitosterol and hydroxy-cinnamic acid. (2007). Possibly 'No' as it does not match with the photographs at eflora site: It has some resemblance to white variety of, Does not match with any species so far in efi site at, Forssk.,Fl. Despite of such elaborative preclinical pharmacological profile, detailed clinical investigations and mechanistic mode-of-action studies of this important herb are yet to be executed. Taken together, C. prostratus is likely to be the front runner for the clinical phyto-pharmaceutical status for treatment of neurological ailments. Shankhapushpi (Convolvulus pluricaulis Choisy): Validation of the Ayurvedic therapeutic claims through contemporary studies. Major phyto-constituents of Convolvulus prostratus (CP) with their reported medicinal utility. Production of triterpenoid anti-cancer compound taraxerol in Agrobacterium-transformed root cultures of butterfly pea (Clitoria ternatea L.). Table 1 Tseomashko N. E., Terent'Eva E. O., Kodirova D. B., Okhunov I. I., Aripova S. F., Khashimova Z. S., et al. . Methanolic extract of this plant (5001000 mg/Kg) also exhibited anti-convulsant activity, as characterized by reduction in the mean recovery time of convulsions in case of maximal electroshock seizure model in mice (Kaushik, 2017). Tau reduction prevents A-induced defects in axonal transport. : 2 posts by 2 authors. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. (2010). Hepatoprotective potentials of aqueous extract of Convolvulus pluricaulis against thioacetamide induced liver damage in rats, Comparative nootropic effect of Evolvulus alsinoides and Convolvulus pluricaulis, Medhya rasayanas in brain function and disease. and Nardostachys jatamansi (D. Don) DC. and gokhru (Tribulus terrestris L.) in the management of hypertension. Biochem, AMPK activation reduces hepatic lipid content by increasing fat oxidation, The sodium-potassium pump is an information processing element in brain computation. Photographed from Delhi, growing in waste places and roadsides. Subramani R., Anand M., Muralidharan P. (2013). The ethanolic and aqueous extracts of the CP leaves have been evaluated for acute oral toxicity study in albino Wistar rats. Anyways, looks matching with the limited image! Isolation and characterization of glycosides from Convolvulus prostratus, Ficus virens, Phoenix dactifera, Spondias mangifera and Terminalia belerica. A comprehensive review on shankhpushpi a morning glory. Ch., Ramanamam V., Ram S. S., Sudershan M., et al. The .gov means its official. Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation, Current research on antiepileptic compounds. One such cognitive booster herb is C. prostratus Forssk., commonly known as Shankhpushpi, which is mainly endowed with neuroprotective, nootropic and neuro-modulatory activities ( Table 2 PMC legacy view Shankhpushpi has been used traditionally as a brain tonic and is believed to help a wide range of issues. C. prostratus (CP) contains volatile oil; fatty alcohols; flavonoids, i.e. A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines, Attenuating effect of bioactive coumarins from Convolvulus pluricaulis on scopolamine-induced amnesia in mice, ). Besides Ayurveda, C. prostratus (CP) has also been used in Siddha system of medicine, wherein an oil obtained from this plant is used as a keratogenic agent for promoting hair growth (Gogte, 2012). ) (Siddiqui etal., 2014). for a possibility to participate in their field excursions and to learn about local nature. The present review is attempted to showcase the phytochemical profile, pharmacological attributes and medicinal information of C. prostratus; with comprehensive research gap analysis. Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis, Anticonvulsant activity of Shankhapuspi (Convolvulus pluricaulis Chois) on Strychnine induced seizure in experimental animals. about navigating our updated article layout. Besides, role of C. prostratus extracts in neurodegeneration has been well demonstrated. Amin H., Sharma R., Vyas M., Prajapati P. K., Dhiman K. (2014). Moreover, it has also been proposed that the anti-convulsant activity of a phyto-medicine is escalated by the presence of certain functional groups like, quinoline, quinazoline, thiazole, benzothiazines, oxadiazole, pyridine, pyrazole, imidazole, pyrimidine, phthalazine, triazine, triazoles, cyclopropane carboxylate, and oxime ether (Wei etal., 2015; Song and Deng, 2018). (2014). It is also believed that a paste prepared from its roots and flowers act as anti-aging agents, thereby indicating its apparent anti-oxidant activity (Adams etal., 2007). Vossel K. A., Zhang K., Brodbeck J., Daub A. C., Sharma P., Finkbeiner S., et al. These toxicological studies, therefore, confirmed that the administration of CP is safe for the vital organs within the respective treatment durations. Reported mechanisms of CNS action of CP phyto-constituents has been depicted in these schematics, with putative site of action has been marked with fluorescent green blobs. , Hydroxycinnamic acids (HCAS): Structure, biological properties and health effects. Billore K. V., Yelne M. B., Dennis T. J., Chaudhari B. G. (2005). Bhalerao and co-workers have found that the chloroform fraction isolated from the CP ethanolic extract reversed the reserpine-induced extension of immobility period of mice in Forced Swim Test (FST), and elicited a significant antidepressant effect by interaction with adrenergic, dopaminergic and serotonergic systems (Bhalerao etal., 2014). 1 post by 1 author. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Estimation of elemental concentrations of Indian medicinal plants using Energy dispersive X-ray fluorescence (EDXRF). Furthermore, the choline acetyl transferase enzyme is essential for the synthesis of neurotransmitter acetylcholine; and the nerve growth factor-tyrosine kinase A receptor is necessary for binding of the neuronal trophic factors, thereby ensuring the survival of the neurons (Johnson etal., 2018; Indo, 2018). In another similar experiment, the aqueous extract of the CP leaves and flowers showed an evident barbiturate hypnosis potentiation in albino rats at a dose of 300 mg/Kg (Mudgal, 1975). This CP herb has also been reported for several other pharmacological activities, including anti-diabetic, anti-hyperlipidemic, anti-hypertensive, anti-microbial, anti-platelet aggregation, anti-ulcer, cardio-vascular, hepatoprotective, and hypothyroidism (Barar and Sharma, 1965; Mudgal, 1975; Rizk etal., 1985; Mali, 1995; Jain etal., 2011; Ravichandra etal., 2013; Jalwal etal., 2016). In recent years, non-communicable diseases (NCDs) have become an emerging cause of morbidity and mortality (~ 12% global prevalence) (Islam etal., 2014). Bihaqi S. W., Singh A. P., Tiwari M. (2012). You can help Wikipedia by expanding it. Similar views had been presented in Chikitsasangraha written by Chakradatta; Kaideva Nighantu; and Ayurveda Saar Sangraha (Khare, 2004). Additionally, CP removes the formation of thrombus in the carotid artery (G). The CP ethanolic extract has exhibited spasmolytic activity in isolated rabbit ileum, isolated rat uterus, intact intestine and tracheal muscles of dog (Barar and Sharma, 1965). (2012). Aegypt. In cholesterol-fed gerbils shankapushpi was observed to have significantly helped reduce serum cholesterol, low density lipoprotein cholesterol, and triglycerides after ninety days. The presented research work been funded by the research funds of Patanjali Research Foundation Trust (PRFT), Haridwar, India. There are various herbs which are used in traditional medicine for the management of neurodegenerative diseases, for instance: Centella asiatica (L.) Urb., Glycyrrhiza glabra L., Tinospora cordifolia (Willd.) Non-Communicable Diseases (NCDs) in developing countries: a symposium report, Radical scavenging and antimicrobial activities of Convolvulus microphyllus. ) are responsible for such evident neuro-pharmacological profile of the CP plant (Nolte, 1999; Carter, 2014). "Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies", "Phyto-chemistry and pharmacology of shankapushpi four varieties", "An update on Ayurvedic herb Convolvulus pluricaulis Choisy", https://en.wikipedia.org/w/index.php?title=Convolvulus_prostratus&oldid=1092855756, Short description is different from Wikidata, Taxonbars with multiple manual Wikidata items, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 13 June 2022, at 01:25. f. & Thomson, Bacopa monnieri (L.) Wettst. government site. HHS Vulnerability Disclosure, Help In addition, detailed mechanistic studies are yet to be executed to unravel the underlying mechanism of action for this cognition enhancing herb. Moreover, the CP powder and juice, such as, Jain Shankhpushpi Powder and Axiom Jeevan Ras Shankhpushpi Juice, are also being used as skin mask for rejuvenating the skin and managing skin problems such as acne, blemishes and sun spots (Hindu, 2012). This formulation is mainly used for the management of insomnia, drug addiction and hypertension (Bhutya, 2011). Singh V. K., Govil J. N., Hashmi S., Singh G. (2003). 1775. Such extensive industrial uses of CP further confirms the holistic significance of this nontoxic wonder herb (Jalwal etal., 2016). Furthermore, in Unani medicinal system, a syrup prepared with C. prostratus and Piper nigrum is prescribed in bleeding piles and venereal diseases (Khare, 2004). In another experiments, it has been shown that the oral administration of the aqueous extract of the CP roots (150 mg/Kg) to scopolamine induced rats causes a marked reduction in the mRNA levels of tau protein (Bihaqi etal., 2012). Other collections of pictures from Qatar: Full names, synonyms, and classification of plants were found online from catalogueoflife.org and theplantlist.org Zingue S., Foyet H. S., Djiogue S., Ezo'o Ezo'o Y., Abassou H. H. N., Fachagbo P., et al. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: reverse pharmacology and bedside to bench approach. The ensuing sections will provide an ethnomedicinal, phytochemical and pharmacological update of this cognitive booster herb, C. prostratus (CP). Neurological disorders constitute a significant proportion as the leading causes of death among all the other non-communicable diseases (Gourie-Devi, 2014). Jalwal P., Singh B., Dahiya J., Khokhara S. (2016). 1 The ethanolic and chloroform extracts isolated from the aerial parts of CP showed significant anxiolytic activity as recorded using elevated plus maze test on experimental mice. In-Vitro Evaluation of Antioxidant Activity and Total Phenolic Content of Methanolic Extract of Convolvulus pluricaulis, Preliminary pharmacological studies on Convolvulus pluricaulis choisan Indian indigenous herb, Chemical investigation of Convolvulus pluricaulis Chois, Old and new natural products as the source of modern antithrombotic drugs. CP plant also contains other alkaloids (convolamine, convosine, convoline, convolidine, convolvine, confoline, evolvine, phyllabine, subhirsine, sankhpuspine) (Agarwa etal., 2014; Balaji etal., 2014); anthroquinones; carbohydrates (D-glucose, sucrose, rhamnose, maltose) (Dhingra and Valecha, 2007; Bhowmik etal., 2012; Agarwa etal., 2014); coumarins (ayapanin, scopolin, scopoletin); flavonoids (kaempferol, quercetin) (Lal, 2014); glycosides (geranilan-3-ol-1-carboxylate-1-O--D-xylopyranosyl-(21)-O--D-xylopyranoside (Sultana etal., 2018); phenolic compounds; steroids; tannins; and terpenoids (Ravichandra etal., 2013; Agarwa etal., 2014; Balaji etal., 2014; Malik etal., 2016). Prats E., Bazzalo M. E., Len A., Jorrn J. V. (2006). Herbal medicines in neurodegenerative disorders: an evolutionary approach through novel drug delivery system, A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Tonda-Turo C., Origlia N., Mattu C., Accorroni A., Chiono V. (2018). All of these stated medicinal utilities of C. prostratus (CP) have been attributed to various phytoconstituents, belonging to the chemical family of alkaloids, flavonoids, coumarins and polyphenols. This herb exhibits anti-convulsant, anti-depressant, anxiolytic, sedative, anti-inflammatory, anti-oxidant, analgesic, nootropic, spasmolytic and neuroprotective activities. (A) Neuro-mechanistic aspects of Convolvulus prostratus (CP). Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats, https://www.ijser.org/paper/Estimation-of-elemental-concentrations-of-Indian-medicinal-plants-using-Energy-dispersive-X-ray-fluorescence.html, https://www.ijpp.com/IJPP%20archives/1965_9_2/99-102.pdf, https://www.semanticscholar.org/paper/Ethnobotany%2C-Phytochemistry-and-Pharmacology-of-Bhalerao-Verma/62602df9affb6d3a5a27699015e1506aa34ef1bf, http://www.phytojournal.com/vol1Issue1/Issue_may_2012/4.pdf, https://www.semanticscholar.org/paper/SCREENING-FOR-ANTIDEPRESSANT-LIKE-ACTIVITY-OF-IN-Dhingra-Valecha/51168240f3c88647a52ce21a54878606c61a7c66, https://irjponline.com/admin/php/uploads/794_pdf.pdf, https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/1109757, http://www.thepharmajournal.com/archives/?year=2016&vol=5&issue=1&ArticleId=695, https://pdfs.semanticscholar.org/1dc0/39b0046a0caa7e211b7a64f0ec91596d4fef.pdf, https://www.pharmatutor.org/articles/development-high-performance-thin-layer-chromatography-method-for-determination-scopolin-convolvulus-pluricaulis-chois?page=1%2C1, https://www.researchgate.net/publication/266140204_Hypolipidemic_effect_of_Convolvulus_microphyllus_in_cholesterol_fed_gerbils_Meriones_hurrinae_Jerdon, https://www.semanticscholar.org/paper/Review-on-ethnomedicinal-uses-and-of-memory-herb-Sethiya-Mishra/427692942318bd7bf5c9cd65e2cf8627aaa9c61f, http://globalresearchonline.net/journalcontents/v23-2/36.pdf, https://www.semanticscholar.org/paper/REVIEW-OF-SANKHAHAULI-(CONVOLVULUS-PLURICAULIS-FROM-Nisar-Khan/0994b296aed35c7b9ccaa97be1505fddf55218e8, https://www.ijam.co.in/index.php/ijam/article/view/163, https://ijpbs.net/abstract.php?article=NTk2, http://nopr.niscair.res.in/handle/123456789/27919, http://www.phytojournal.com/archives/2013/vol2issue4/PartB/23.1.pdf, https://pdfs.semanticscholar.org/696f/2e4d7280727d2baba08bc7c6e3a7cd03ef3a.pdf, Decoction of this herb used along with milk (, Intact parts used for treating anxiety neurosis (, Whole plant used for the management of arthritis, osteoarthritis and rheumatic pain (, Paste of flowers and leaves used for the management of fracture (, Intact parts used for the management of constipation (, Paste of roots and flowers administered for the treatment of dementia (, Paste of leaves (100 g) along with black pepper (3-4 grains) is to be administered once daily (, Jelly obtained from this plant (10 g) is mixed with honey (10 g) and is to be taken thrice a day (, Paste of this plant along with cumin seeds (l g) and milk thrice a day (, Juice of the leaves has to be administered at a dose of 10 mL, thrice a day (, Powder of plant (3 g) mixed with sugar (5 g) and milk (20 ml) is to be taken twice daily (, Paste of this plant is taken along with milk (, Decoction of this herb is used along with cumin and milk for treating attention deficit hyperactivity disorder (ADHD), mild convulsions, depression, emotional stress, mental debility, memory loss, mental hypersensitivity, schizophrenia and stress disorders (, Intact parts used for the management of excessive thirst (, Intact parts used for alleviating fever (, Intact parts used for the management of heart burn or pyrosis (, Decoction of this herb is used along with cumin and milk (, This plant (100 g) is ground with little water and taken with sugar or honey once daily, for 21 days (, One tea spoon powder of dried plant is taken for the management of stomachache (, A syrup prepared from this herb is used for the management of vertigo (, Improves scopolamine-induced spatial memory impairment (, Antihypoxic, immune-modulating, and anti-inflammatory activity (, Antioxidant, anti-mutagenic, anti-inflammatory and antiangiogenic (, Antioxidant, photooxidant activity; strong inhibitory effect on the tumour U14 (, Activates LXR- and suppresses SREBP-1 to enhance symptoms in metabolic syndromes; potent inhibitory effect on, Antioxidant activity; stimulator of recombinant SIRT1 and also a PI3K inhibitor; attenuated the function VEGFR, androgen receptor and the expressions of NF-B, IL Receptor, FAK, ERK, Nrf2 (, Antifungal, anti-allergic, anti-aging and hypouricemic activities (, Antinociceptive activity; acetylcholinesterase (AChE) inhibitor; fungitoxic activity (, Anti-inflammatory; anti-cancerous activity (, Anti-inflammatory; anti-proliferation; anti-pyretic; pro-apoptotic activity (.
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