neoleukin therapeutics wiki
neoleukin therapeutics wiki
For monitoring T cell infiltration and activation, an anti-ADP-ribosyltransferase-2 (ART-2) nanobody demonstrated T cell tracking and unexpected therapeutic potential through ART-2 inhibition (42). Lv G, Sun X, Qiu L, Sun Y, Li K, Liu Q, et al. Oncotarget. Thus, nanobodies form quite suitable candidates, ensuring minimal non-target retention to create a high tumor-to-background ratio (T/B) shortly after administration. Ezekowitz RA, Gordon S. Alterations of surface properties by macrophage activation: expression of receptors for Fc and mannose-terminal glycoproteins and differentiation antigens. Adv Drug Deliv Rev. Mol Pharm. Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, et al. doi: 10.1083/jcb.201502074, 217. The serendipitous discovery of heavy-chain only antibodies (HcAbs) in camelids sparked the most recent wave of third generation antibodies. However, a recent study found that intra-arterial administration of nanobody imaging probes dramatically enhanced delivery regardless of BBB status (218), suggesting a potential avenue for circumventing BBB limitations. Yang YSS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, et al. (57) reported DNA immunization-raised EGFR nanobodies with improved functionality compared to protein immunization-raised nanobodies. Eur J Cancer. Carcinoembryonic antigen (CEA)-specific 4-1BB-costimulation induced by CEA-targeted 4-1BB-agonistic trimerbodies. (2017) 3:17004. doi: 10.1038/celldisc.2017.4, 78. 1. Ahn S, Li J, Sun C, Gao K, Hirabayashi K, Li H, et al. (2016) 229:93105. With mixed clinical success, mAbs still hold significant shortcomings, as they possess limited tumor penetration, high manufacturing costs, and the potential to develop therapeutic resistance. doi: 10.1096/fj.01-0343fje, 8. In vivo near-infrared fluorescence targeting of T cells: Comparison of nanobodies and conventional monoclonal antibodies. doi: 10.1016/j.jconrel.2011.12.007, 13. doi: 10.1038/srep03571, 112. (2016) 9:315362. Mol Pharm. (2013) 12:41626. doi: 10.1007/s10529-013-1340-1, 62. Oncoimmunology. Nanobodies as tools for in vivo imaging of specific immune cell types. PET imaging of tumor PD-L1 expression with a highly specific nonblocking single-domain antibody. Isolation of TGF--neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing. Enter your email address so we can get in touch. doi: 10.1158/1535-7163.MCT-12-0731, 69. Wan R, Liu A, Hou X, Lai Z, Li J, Yang N, et al. doi: 10.1186/s13046-019-1259-z, 77. Van de Water et al. The development of targeted medicine has greatly expanded treatment options and spurred new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging as a prevalent treatment in recent years. Fleming BD, Urban DJ, Hall M, Longerich T, Greten T, Pastan I, et al. An anti-L-plastin nanobody was reported to augment T cell proliferation and IL-2 secretion, but this has also not been studied in tumors (157). Development by genetic immunization of monovalent antibodies (nanobodies) behaving as antagonists of the human chemr23 receptor. Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, et al. Although not as highly explored, the utilization of nanobody-secreting carriers could circumvent such issues by ensuring both continuous and localized delivery. (1993) 363:4468. (165) developed an enhanced anti-HER2-PE toxin that improved both efficacy and the maximum tolerated dose. doi: 10.1080/21691401.2017.1369426, 91. J Control Release. Mol Pharm. Similarly, bispecific light T-cell engagers (LiTEs) targeting EGFR and CD3 have demonstrated T cell-mediated tumor lysis with minimal cytotoxicity (100). (2019) 120:1078795. Both authors contributed to the article and approved the submitted version. Mol Cancer Ther. Small. Chen J, Guo H, Jiang H, Namusamba M, Wang C, Lan T, et al. Blood. Van De Water JAJM, Bagci-Onder T, Agarwal AS, Wakimoto H, Roovers RC, Zhu Y, et al. (2017) 9:30297305. Bioconjug Chem. (2020) 18:12. doi: 10.1186/s12951-020-0571-2, 88. Artif Cells Nanomed Biotechnol. Xing Y, Chand G, Liu C, Cook GJR, O'Doherty J, Zhao L, et al. Hassani M, Hajari Taheri F, Sharifzadeh Z, Arashkia A, Hadjati J, van Weerden WM, et al. Eur J Haematol. Nanobody targeting of epidermal growth factor receptor (EGFR) ectodomain variants overcomes resistance to therapeutic EGFR antibodies. Altintas I, Heukers R, Van Der Meel R, Lacombe M, Amidi M, Van Bergen En Henegouwen PMP, et al. Behdani M, Zeinali S, Khanahmad H, Karimipour M, Asadzadeh N, Azadmanesh K, et al. doi: 10.1016/j.molimm.2019.02.022, 211. Furthermore, nanobodies designed to neutralize TNF (143), IL-23 (144), granulocyte colony-stimulating factor receptor (G-CSF-R) (145), and transforming growth factor beta (TGF-) (146) have demonstrated success in vitro (145), and in vivo (143, 144). doi: 10.1016/j.jconrel.2014.12.039. Wang Y, Liu J, Pan H, Xing J, Wu X, Li Q, et al. A nanobody against cytotoxic t-lymphocyte associated antigen-4 increases the anti-tumor effects of specific cd8+ T cells. (2018) 10:104559. Table 1. (2018) 115:39127. Proc Natl Acad Sci USA. ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy. Biomater Sci. doi: 10.1097/CJI.0000000000000200, 126. (2007) 56:30317. Int J Mol Sci. (2014) 5:530419. Liu Y, Wang Y, Xing J, Li Y, Liu J, Wang Z. Patient-derived head and neck cancer organoids recapitulate egfr expression levels of respective tissues and are responsive to EGFR-targeted photodynamic therapy. Bian X, Wu P, Sha H, Qian H, Wang Q, Cheng L, et al. doi: 10.1002/iub.2019, 108. Co-delivery of simvastatin/gefitinib using anti-PD-L1-nanobody liposomes reversed tyrosine kinase inhibitor (TKI) resistance, addressing a major treatment obstacle in non-small-cell lung cancers (NSCLC) (179). J Control Release. Some target DC surface proteins such as CD11b (128, 129), CD36 (128), and MHC-II (128, 130), and others have been designed to block ICPs CTLA-4 (131), and PD-L1 (132) to enhance DC-mediated T cell activation. VHH-photosensitizer conjugates for targeted photodynamic therapy of met-overexpressing tumor cells. Nanobody-Functionalized polymersomes for tumor-vessel targeting. Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers. A phase I/II trial will assess the overall response rate to T cells expressing anti-mesothelin nanobodies fused to the endogenous TCR (NCT03907852). A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Int J Mol Sci. (2018) 13:3189201. Oliveira S, Schiffelers RM, van der Veeken J, van der Meel R, Vongpromek R, van Bergen en Henegouwen PMP, et al. Table 4. Ultrasound imaging utilizes reflected sound waves from tissues, and nanobodies have been tagged to contrast agents, microbubbles, and nanobubbles. In general, antigen specificity is determined at the exposed ends of each variable domain through three peptide loops, or complementarity determining regions (CDRs). doi: 10.1007/s00005-012-0206-x, 141. Generation and characterization of a functional nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor. Contrast Media Mol Imaging. FASEB J. Gene Ther. Sci Rep. (2016) 6:27055. doi: 10.1038/srep27055, 165. It is also a comparatively safer technique, but its applications are currently limited to systemic vasculature (12). (2018) 15:145766. Open Biol. Generation and characterization of a functional nanobody against inflammatory chemokine CXCL10, as a novel strategy for the treatment of multiple sclerosis. (2017) 8:4193246. Proc Natl Acad Sci USA. (2019) 20:2088. doi: 10.1101/388884, 210. Saqafi B, Rahbarizadeh F. Polyethyleneimine-polyethylene glycol copolymer targeted by anti-HER2 nanobody for specific delivery of transcriptionally targeted tBid containing construct. Massa PE, Paniccia A, Monegal A, De Marco A, Rescigno M. Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas. (2019) 10:365. doi: 10.1038/s41467-018-08172-z, 75. "A First-in-Human Phase 1 Study of NL-201 in Patients With Relapsed or Refractory Cancer", "De novo design of potent and selective mimics of IL-2 and IL-15", "Another publication in Nature describing the first de novo designed proteins with anti-cancer activity", "NL-201: A de novo CD25-independent combined IL-2 and IL-15 receptor agonistdesigned to selectively stimulate anti-tumor CD8+ effector T and NK cells", "Neoleukin Therapeutics Announces Initiation of Phase 1 NL-201 Trial | Neoleukin Therapeutics, Inc", "Neoleukin Therapeutics Announces Clinical Collaboration with Merck to Evaluate NL-201 in Combination with KEYTRUDA (pembrolizumab) | Neoleukin Therapeutics, Inc", https://en.wikipedia.org/w/index.php?title=NL-201&oldid=1100823377, Antineoplastic and immunomodulating drug stubs, Articles containing potentially dated statements from May 2021, All articles containing potentially dated statements, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 27 July 2022, at 22:10. (2019) 109:129. Transl Oncol. (2012) 158:34653. (2019) 58:142248. (2003) 77:276874. Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy. J Nucl Med. doi: 10.2217/imt-2016-0049, 99. (2019) 8:26. doi: 10.3390/antib8020026, 206. J Biol Chem. (2019) 25:105763. Cancer Metastasis Rev. Oncotarget. Similarly, Gurbatri et al. (2019) 16:21426. Henry KA, Hussack G, Collins C, Zwaagstra JC, Tanha J, Mackenzie CR. Romo E, Krasniqi A, Maes L, Vandenbrande C, Sterckx YGJ, Stijlemans B, et al. (2019) 20:2597. doi: 10.3390/ijms20102597, 152. Possessing such a highly modular nature has propelled a wide array of nanobody-fusion molecules (Figure 1B). (2018) 19:403. doi: 10.3390/ijms19020403, 113. (2020) 12:eaax0876. Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. (2013) 70:90922. However, like T cell-based therapies, their potency remains stunted in solid tumors, particularly from limited tissue penetration and immunosuppression. Notably, the bacterial type III protein secretion system (T3SS) has been utilized to deliver nanobodies into tumor cells. Protein Expr Purif. doi: 10.1007/s10555-005-6193-1, 12. Efficient cancer therapy with a nanobody-based conjugate. Kunz P, Zinner K, Mcke N, Bartoschik T, Muyldermans S, Hoheisel JD. (2017) 386:2434. Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, et al. Immunotherapy. Cell Res. (2016) 59:30512. (2012) 50:3541. Xavier C, Blykers A, Laoui D, Bolli E, Vaneyken I, Bridoux J, et al. Nanobody-coupled microbubbles as novel molecular tracer. Sadeghnezhad G, Romo E, Bernedo-Navarro R, Massa S, Khajeh K, Muyldermans S, et al. Xian Z, Ma L, Zhu M, Li G, Gai J, Chang Q, et al. This could be attributed to their relative infancy as a cancer therapeutic, heightened by the 2012 clinical trial of a tetravalent nanobody targeting DR5, which was terminated due to unanticipated hepatoxicity (NCT01529307). (2018) 12:57588. doi: 10.3791/57588, 128. Report Locked. A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth. (2018) 40:36874. Thus, the surface fusion of nanobodies can increase their target specificity. Lesniak WG, Chu C, Jablonska A, Behnam Azad B, Zwaenepoel O, Zawadzki M, et al. Roovers RC, Laeremans T, Huang L, De Taeye S, Verkleij AJ, Revets H, et al.
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